Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine. Charbit, B., Becquemont, L., Lepere, B., Peytavin, G., and Funck-Brentano, C.The effects of grapefruit juice on the pharmacokinetics of erythromycin. Effects of grapefruit juice and smoking on verapamil concentrations in steady state. Fuhr U, Muller-Peltzer H, Kern R, et al.Effects of grapefruit juice on the pharmacokinetics of sildenafil. Jetter A, Kinzig-Schippers M, Walchner-Bonjean M, et al.Grapefruit juice-simvastatin interaction: effect on serum concentrations of simvastatin, simvastatin acid, and HMG-CoA reductase inhibitors. Grapefruit juice increases serum concentrations of atorvastatin and has no effect on pravastatin. Well-controlled human studies have demonstrated the likely existence of this interaction While all patients are at risk for interactions with grapefruit juice consumption, patients older than 70 years of age and those taking multiple medications are at the greatest risk for a serious or fatal interaction with grapefruit juice.
#Grapefruit and atorvastatin interaction professional
Professional consensus recommends the consideration of patient age, existing medical conditions, additional medications, and the potential for additive adverse effects when evaluating the risks of concomitant use of grapefruit juice with any medication metabolized by CYP3A4. When taken orally, effects of grapefruit juice on CYP3A4 levels appear to last at least 48 hours.
Grapefruit juice can increase levels of drugs metabolized by CYP3A4.Ĭlinical research shows that grapefruit juice can inhibit CYP3A4 metabolism of drugs, causing increased drug levels and potentially increasing the risk of adverse effects. There are multiple interactions reported between these two agents.Ītorvastatin Calcium is classified as belonging to the following
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